We are studying associations of polymorphisms in genes encoding molecules controling immune reactions (KIR, CTLA-4, HLA-C, HLA-B, HLA-G, PTPN22, TGFB1) with human diseases (rheumatoid arthritis, ankylosing spondylitis, spontaneous abortions – both recurrent and sporadic, psoriasis, atopic dermatitis, multiple sclerosis, non-small-cell lung carcinoma, cryptorchidism, kidney graft rejection, outcome of hematopoietic stem cell transplantation)
We undertake population-based study of minor histocompatibility antigens.
Human minor histocompatibility antigens (mHa ) are allogeneic target molecules having significant roles in alloimmune responses after HLA matched solid organ and stem cell transplantation, in processes of transplant rejection, graft-versus-host disease and in the curative graft-versus-tumor effect. Little is know on their phenotypic distribution and antigen frequencies in various populations.
The recent discoveries of the transfer, persistence and presumed differentiation of chimeric cells formed during pregnancy (microchimerism), has induced some questions of the role of such cells in health and disease. We conduct research on the possible role of microchimerism in pathogenesis of some diseases.